Ii. Role of Excitatory Amino Acid Receptors in Seizures
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P24: The Role of Ionotropic Glutamate Receptors in the Induction of LTP
Long-term potentiation (LTP) is a reflection of synaptic plasticity that has an important role in learning and memory. LTP is a long-lasting increase of synaptic activity due to enhancement of excitatory synaptic transmission after a high-frequency train of electrical stimulation. The role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in excitatory synaptic tran...
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EXCITATORY AMINO ACIDS IN EPILEPSY 133 5.1. Background 133 5.1.1. Classification of excitatory amino acid receptors 133 5.2. Role of Excitatory Amino Acids in Transmission of Hyperactivity 133 5.3. Role of excitatory amino acids in Primary Events 135 5.3.1. Convulsions induced by glutamate 135 5.3.2. Excitotoxic action 135 5.3.3. Neurotoxic lesions as epileptic foci 136 5.3.4. Quinolinic acid 1...
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Seizurogenic chemicals include a variety of toxic agents, including chemical warfare agents, toxic industrial chemicals, and natural toxins. Chemical weapons such as sarin and VX, and pesticides such as parathion and carbaryl cause hyperstimulation of cholinergic receptors and an increase in excitatory neurotransmission. Glutamatergic hyperstimulation can occur after exposure to excitatory amin...
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